Active Studies
Use the “Contact Us” buttons to access virtual interest forms or email addresses so a research study staff member may contact you. All of our studies compensate for participants’ time and efforts.
BD2 Integrated Network Longitudinal Cohort Study
An observational, longitudinal study for adults diagnosed with bipolar I disorder taking place at multiple institutions, with the objective of deepening our understanding of bipolar disorder at a clinical, cognitive, and biological level. This study does not include any type of investigational intervention or therapy.
ALTO-100-211: A Randomized, Double-Blind, Placebo-Controlled Study Followed by Open-Label Treatment of ALTO-100 In Adults with Bipolar Disorder Currently Experiencing a Major Depressive Episode
This study is a placebo-controlled clinical trial for patients age 18-70 years old with bipolar disorder type I or type II, currently experiencing a depressive episode. Study procedures include, but are not limited to, clinical assessment, electroencephalography (EEG), blood collection, and neurocognitive assessment.
Sequential Multiple Assignment Randomized Trial for Bipolar Depression (SMART-BD)
This is a sequential, multiple assignment randomized clinical trial for adults with a bipolar disorder I or II diagnosis currently experiencing a depressive episode. This multi-site study will assess effectiveness of four commonly prescribed treatments for bipolar depression. There is no placebo group.
Enhancing Value-Based Care for Bipolar Youth and Their Families
This pragmatic, open-label research study combines clinical care and a 6-week psychoeducation course for youth age 14-25 diagnosed with bipolar disorder and their family members. Both participants and enrolled family members will complete a clinical diagnostic assessment, self-report surveys, and be compensated for their time.
To consent for this study, youth under age 18 must have a parent/guardian present to co-sign.
Longitudinal Bipolar Alcohol Consumption Study
Investigators are studying experiences of alcohol intoxication and related brain development and behavior during young adulthood. The purpose of the study is to investigate how the brain responds to alcohol overtime and related brain changes in bipolar disorder and compare these effects among individuals who do not have bipolar disorder.
Active Studies of Associated Collaborators
Building Mood State Classifiers to Inform Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
An interventional study to test if deep brain stimulation (DBS), a neurosurgical procedure widely used in movement disorders, is effective and safe in 10 patients with bipolar depression. To reduce the risk of inducing mania, emerging signs such as decreased need for sleep, increased activity, rapid speech, and elevated mood will be monitored using a variety of mobile monitoring methods (e.g., wearables, smartphone readouts, audio diaries, etc.) together with recording of brain activity by the DBS device.
Recruitment Starting Soon
Neural Characteristics and Cognitive Functioning of Youth with Bipolar Disorder (NECTARY Plus)
An observational study for adolescents/young adults diagnosed with bipolar disorder to investigate clinical, cognitive, and neuroimaging biomarkers for the disorder.
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Lumateperone for the Treatment of Major Depressive Episodes Associated with Bipolar I or Bipolar II Disorder in Pediatric Patients
This multi-site study is a placebo-controlled clinical trial for studying the use of lumateperone in patients age 10-17 years old with bipolar depression. Total time in study is ~9 weeks.
Closed Studies
Leveraging a Collaborative Network to Test TMS treatment for Bipolar Depression
To build a framework for collaborative TMS studies in bipolar depression guided by neuroimaging and neuronavigation using the Stanford Neuromodulation Treatment protocol.
A Randomized, Double-Blind Controlled Comparison of NRX-101 to Lurasidone for Adults with Bipolar Depression and Subacute Suicidal Ideation or Behavior
To determine whether patients with Severe Bipolar Depression and subacute Suicidal Ideation or Behavior (i.e. those not requiring inpatient care) can be treated effectively with NRX-101.
A Randomized, Stratified, Double-blind, Placebo-Controlled Study to Investigate the Efficacy, Safety and Tolerability of JNJ-55308942 in Bipolar Depression
To evaluate the efficacy of an investigational medication compared to placebo on symptoms of depression in participants with bipolar disorder in a major depressive episode.
Oxygenating the Brain with Laser Stimulation Therapy to Improve Cognitive Function in Bipolar Disorder
To rigorously test Transcranial Infra-red Laser Stimulation as a novel, non-invasive, and non-pharmacologic intervention for cognitively impaired individuals with bipolar disorder.
The Cost of Bipolar Disorder Misdiagnosis and Associated Savings with a Specialized Program Model
To screen for bipolar disorder illness in the UT Austin and UT Administration and treat using the 6-week program model in the bipolar disorder center.
A Randomized, Double-Blind Trial Assessing the Effects of SAINT Neuromodulation on Suicidal Cognition
A sham-controlled clinical trial of an accelerated intermittent theta-burst stimulation protocol for treatment-resistant unipolar depression with suicidal cognitions.
Neurodevelopmental and Clinical Trajectories of Youth at Risk for Bipolar I Disorder (NECTARY)
The goals of the research are to better understand brain development underlying risk for bipolar disorder by using longitudinal neuroimaging to identify the neurophysiological and clinical predictors of emerging illness in youth with parental risk for bipolar disorder.