Bipolar Disorder Research Center

Active Studies

Use the “Contact Us” buttons to access virtual interest forms or email addresses so a research study staff member may contact you.

Sequential Multiple Assignment Randomized Trial for Bipolar Depression (SMART-BD)

This is a sequential, multiple assignment randomized clinical trial for adults with a bipolar disorder I diagnosis currently experiencing a depressive episode. This multi-site study will assess effectiveness of four commonly prescribed treatments for bipolar depression. There is no placebo group.

Neurodevelopmental and Clinical Trajectories of Youth at Risk for Bipolar I Disorder (NECTARY)

The goals of the research are to better understand brain development underlying risk for bipolar disorder by using longitudinal neuroimaging to identify the neurophysiological and clinical predictors of emerging illness in youth with parental risk for bipolar disorder.

Longitudinal Bipolar Alcohol Consumption Study

Investigators are studying experiences of alcohol intoxication and related brain development and behavior during young adulthood. The purpose of the study is to investigate how the brain responds to alcohol overtime and related brain changes in bipolar disorder and compare these effects among individuals who do not have bipolar disorder.

A Randomized, Double-Blind Trial Assessing the Effects of SAINT Neuromodulation on Suicidal Cognition

A sham-controlled clinical trial of an accelerated intermittent theta-burst stimulation protocol for treatment-resistant unipolar depression with suicidal cognitions.

BD2 Integrated Network Longitudinal Cohort Study

An observational, longitudinal study for adults diagnosed with bipolar I disorder taking place at multiple institutions, with the objective of deepening our understanding of bipolar disorder at a clinical, cognitive, and biological level.

Neural Characteristics and Cognitive Functioning of Youth with Bipolar Disorder (NECTARY Plus)

An observational study for adolescents/young adults diagnosed with bipolar disorder to investigate clinical, cognitive, and neuroimaging biomarkers for the disorder.

Leveraging a Collaborative Network to Test TMS treatment for Bipolar Depression

To build a framework for collaborative TMS studies in bipolar depression guided by neuroimaging and neuronavigation using the Stanford Neuromodulation Treatment protocol.

A Randomized, Double-Blind Controlled Comparison of NRX-101 to Lurasidone for Adults with Bipolar Depression and Subacute Suicidal Ideation or Behavior

To determine whether patients with Severe Bipolar Depression and subacute Suicidal Ideation or Behavior (i.e. those not requiring inpatient care) can be treated effectively with NRX-101.

A Randomized, Stratified, Double-blind, Placebo-Controlled Study to Investigate the Efficacy, Safety and Tolerability of JNJ-55308942 in Bipolar Depression

To evaluate the efficacy of an investigational medication compared to placebo on symptoms of depression in participants with bipolar disorder in a major depressive episode.

Oxygenating the Brain with Laser Stimulation Therapy to Improve Cognitive Function in Bipolar Disorder

To rigorously test Transcranial Infra-red Laser Stimulation as a novel, non-invasive, and non-pharmacologic intervention for cognitively impaired individuals with bipolar disorder.

The Cost of Bipolar Disorder Misdiagnosis and Associated Savings with a Specialized Program Model

To screen for bipolar disorder illness in the UT Austin and UT Administration and treat using the 6-week program model in the bipolar disorder center.